Welcome to the Pallesen Lab at Indiana University Bloomington

Jesper Pallesen — Publications

Publications

2019 von Bredow B, Andrabi R, Grunst M, Grandea AG 3rd, Le K, Song G, Berndsen ZT, Porter K, Pallesen J, Ward AB, Burton DR, Evans DT.
"Differences in the Binding Affinity of an HIV-1 V2 Apex-Specific Antibody for the SIVsmm/mac Envelope Glycoprotein Uncouple Antibody-Dependent Cellular Cytotoxicity from Neutralization."
MBio. 2019 Jul 2;10(4).

2019 Andrabi R*, Pallesen J*, Allen JD, Song G, Zhang J, de Val N, Gegg G, Porter K, Su CY, Pauthner M, Newman A, Bouton-Verville H, Garces F, Wilson IA, Crispin M, Hahn BH, Haynes BF, Verkoczy L, Ward AB, Burton DR.
"The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template."
Cell Rep. 2019 May 21;27(8):2426-2441.e6.

2019 Turner HL*, Pallesen J*, Lang S, Bangaru S, Urata S, Li S, Cottrell CA, Bowman CA, Crowe JE Jr, Wilson IA, Ward AB.
"Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains."
PLoS Biol. 2019 Feb 4;17(2):e3000139.

2018 Laursen NS, Friesen RHE, Zhu X, Jongeneelen M, Blokland S, Vermond J, van Eijgen A, Tang C, van Diepen H, Obmolova G, van der Neut Kolfschoten M, Zuijdgeest D, Straetemans R, Hoffman RMB, Nieusma T, Pallesen J, Turner HL, Bernard SM, Ward AB, Luo J, Poon LLM, Tretiakova AP, Wilson JM, Limberis MP, Vogels R, Brandenburg B, Kolkman JA, Wilson IA.
"Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin."
Science. 2018 Nov 2;362(6414):598-602.

2018 Kirchdoerfer RN, Wang N, Pallesen J, Wrapp D, Turner HL, Cottrell CA, Corbett KS, Graham BS, McLellan JS, Ward AB.
"Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis."
Sci Rep. 2018 Oct 24;8(1):15701.

2018 Saphire EO, Schendel SL*, Fusco ML*, Gangavarapu K*, Gunn BM*, Wec AZ*, Halfmann PJ*, Brannan JM*, Herbert AS*, Qiu X*, Wagh K*, He S, Giorgi EE, Theiler J, Pommert KBJ, Turner HL, Murin CD, Pallesen J, Davidson E, Ahmed R, Aman MJ, Bukreyev A, Burton DR, Crowe Jr. JE, Georgiou G, Krammer F, Kyratsous CA, Lai J, Nykiforuk C, Takada A, Townsend AR, Volchkov V, Walker LM, Wang CI, Zeitlin L, Doranz BJ, Ward AB, Korber B, Kobinger GP, Andersen KG, Kawaoka Y, Alter G, Chandran K, Dye JM for the Viral Hemorrhagic Fever Immunotherapeutic Consortium.
"Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection."
Cell 2018 Aug 9;174(4):938-952.e13.

2018 Kefauver JM, Saotome K, Dubin AE, Pallesen J, Cottrell CA, Hong G, Cahalan SM, Qiu Z, Crowley CS, Whitwam T, Lee WH, Ward AB, Patapoutian A.
"Structure of the Human Volume Regulated Anion Channel."
eLife 2018 Aug 10;7. pii: e38461

2018 Sarkar A, Bale S, Behrens AJ, Kumar S, Sharma S, de Val N, Pallesen J, Irimia A, Diwanji D, Stanfield R, Ward A, Crispin M, Wyatt R, Wilson IA.
"Crystal structure of a cleavage-independent, soluble HIV Env recapitulates the architecture and glycosylation of the native cleaved trimer."
Nat Commun. 2018 May 16;9(1):1956.

2018 Schiffner T*, Pallesen J*, Dodd J*, Russell R*, de Val N, LaBranche C, Montefiori D, Tomaras G, Shen X, Sanders R, McCoy L, Moore J, Ward AB, Sattentau QJ.
"Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins."
PLoS Pathog. 2018 May 10;14(5):e1006986.

2017 Pallesen J*, Wang N*, Corbett KS*, Wrapp D, Kirchdoerfer RN, Turner HL, Cottrell CA, Becker MM, Wang L, Shi W, Kong W, Kettenbach AN, Denison MR, Chappell JD, Graham BS, Ward AB, McLellan JS.
"Immunogenicity and Structures of a Rationally Designed Prefusion MERS-CoV Spike Antigen."
Proc Natl Acad Sci USA. 2017 Aug 29;114(35):E7348-E7357.

2017 Ozorowski G*, Pallesen J*, de Val N, Lyumkis D, Cottrell CA, Torres JL, Copps J, Stanfield RL, Cupo A, Pugach P, Moore JP, Wilson IA, Ward AB.
"Open and Closed Structures Reveal Allostery and Pliability in the HIV-1 Envelope Spike."
Nature. 2017 Jul 20;547(7663):360-363.

2017 van Gils MJ, van den Kerkhof TL, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW, Schorcht A, Gumbs S, Johanna I, Saye-Francisco K, Liang CH, Landais E, Nie X, Pritchard LK, Crispin M, Kelsoe G, Wilson IA, Schuitemaker H, Klasse PJ, Moore JP, Burton DR, Ward AB, Sanders RW.
"An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability."
Nat Microbiol. 2016 Nov 14;2:16199.

2016 Pallesen J*, Murin CD*, de Val N, Cottrell CA, Hastie KM, Turner HL, Fusco ML, Flyak AI, Zeitlin L, Crowe JE Jr, Saphire EO, Ward AB.
"Structures of Ebola Virus GP and sGP in Complex with Therapeutic Antibodies."
Nat Microbiol. 2016;1 pii: 16128. Epub 2016 Aug 8.

2016 Howel KA, Qiu X, Brannan JM, Bryan C, Davidson E, Holtsberg FW, Wec AZ, Shulenin S, Biggins JE, Douglas R, Enterlein SG, Turner HL, Pallesen J, Murin CD, He S, Kroeker A, Vu H, Herbert AS, Fusco ML, Nyakatura EK, Lai JR, Keck ZY, Foung SKH, Saphire EO, Zeitlin L, Ward AB, Chandran K, Doranz BJ, Kobinger GP, Dye JM, Aman MJ.
"Antibody treatment of Ebola and Sudan virus infection via a uniquely exposed epitope within the glycoprotein receptor-binding site."
Cell Reports, 2016 May 17;15(7).

2016 Kirchdoerfer RN*, Cottrell CA*, Wang N, Pallesen J, Yassine HM, Turner HL, Corbett KS, Graham BS, McLellan JS, Ward AB.
"Pre-fusion structure of a human coronavirus spike protein."
Nature. 2016 Mar 3;531(7592):118-21.

2014 Dashti A, Schwander P, Langlois R, Fung R, Li W, Hosseinizadeh A, Liao HY, Pallesen J, Sharma G, Stupina VA, Simon AE, Dinman JD, Frank J, Ourmazd A.
"Trajectories of the ribosome as a Brownian nanomachine."
Proc Natl Acad Sci USA. 2014 Dec 9;111(49):17492-7.

2014 Langlois R, Pallesen J, Ash JT, Ho DN, Rubenstein JL, Frank J.
"Automated particle picking for low-contrast macromolecules in cryo-electron microscopy."
J Struct Biol. 2014 Apr;186(1):1-7.

2013 Pallesen J et al.
"Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1."
eLife 2013;2:e00411

2013 Langlois R, Ash J, Pallesen J, Frank J.
"Fully Automated Particle Selection and Verification in Single-Particle Cryo-EM."
In “Proceedings of Minisymposium on Computational Methods in Three-Dimensional Microscopy Reconstruction”

2013 Sharma G*, Pallesen J*, Das S*, Grassucci R, Langlois R, Hampton CM, Kelly DF, des Georges A, Frank J.
"Affinity grid-based cryo-EM of PKC binding to RACK1 on the ribosome."
J Struct Biol. 2013 Feb;181(2):190-4.

2011 Langlois R, Pallesen J, Frank J.
"Reference-free particle selection enhanced with semi-supervised machine learning for cryo-electron microscopy."
J Struct Biol. 2011 Sep;175(3):353-61.

2011 Pallesen J.
"Structure of the HIV-1 5´UTR dimer alone and in complex with gold colloids. Support of a TAR-TAR containing 5` dimer linkage site (DLS) and a 3`DIS-DIS containing DLS."
Biochemistry 2011 Jul 19;50(28):6170-7.

2010 Sengupta J, Bussiere C, Pallesen J, West M, Johnson AW, Frank J.
"Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit."
J Cell Biol. 2010 Jun 28;189(7):1079-86.

2009 Pallesen J, Dong M, Besenbacher F, Kjems J.
"Structure of the HIV-1 Rev response element alone and in complex with regulator of virion (Rev) studied by atomic force microscopy."
FEBS J. 2009 Aug;276(15):4223-32.